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For women with obesity-related infertility, particularly those with PCOS or anovulation, the weight loss achieved with GLP-1 receptor agonists can restore reproductive function

Initially described as a mediator of exercise-induced browning of white adipose tissue and increased energy expenditure, irisin was proposed as a candidate exercise- associated signaling molecule ( Subsequent debate regarding assay specificity, circulating concentrations, and translational relevance led to skepticism regarding irisins role in humans

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