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However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS
Choosing to use them is essentially a reasoned bet that findings in animal models will translate to humans plausible based on the underlying mechanisms, but not yet proven
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As the hepatic T4 to T3 conversion is stimulated in response to feeding 16 , the role of hepatic TH signaling in the metabolic response to nutrient ingestion has been of interest
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