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In a substudy of 178 patients from the SUSTAIN 8 trial on semaglutide as a diabetes treatment, the average proportion of lean mass loss was nearly identical at 40%, despite lower doses and less total weight loss than in the STEP 1 trial

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Creatine supplementation has been shown to down-regulate the synthesis of l-arginine : glycine amidinotransferase and consequently reduce endogenous formation of creatine, changing the methylation flux and reducing Hcy synthesis ( Reference Taes, Delanghe and De Vriese 6 , Reference Stead, Au and Jacobs 20 )

A1 is the absorbance value of the standard tube - absorbance value of the blank group