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NMNATs catalyze adenylation of nicotinamide mononucleotide to produce NAD +
iScience 26:108098
Medical Evaluation Investigate potential medical contributors to weight loss resistance: Thyroid function: Check TSH if not recently assessed, as hypothyroidism impairs weight loss Medications: Review for weight-promoting drugs (antipsychotics, certain antidepressants, corticosteroids) Sleep disorders: Screen for sleep apnea and insufficient sleep, both associated with weight loss resistance Stress and cortisol: Chronic stress elevates cortisol, promoting central adiposity and metabolic dysfunction Dose Optimization If patients have not reached the maximum tolerated dose, consider further titration according to FDA labeling
UK Biobank: OR = 0.99, 95% CI [0.99, 0.99])
