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Anecdotal reports include mild lethargy or head-pressure during loading phases, but these are not RCT-verified
47 Large GWAS meta-analyses of BE and EAC have identified several novel risk loci, including CFTR (rs17451754, P = 4.8 10), MSRA (rs17749155, P = 5.2 10), TPPP and CEP72 (rs9918259, P = 3.2 10), TMOD1 (rs7852462, P = 1.5 10), FMNL2 (rs12987825, P = 3.88 10), SLC66A1L (rs60849513, P = 9.56 10 11 ), HTR3C and ABCC5 (rs9823696, P = 1.6 10)
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Prebiotics also influence bile acid metabolism by modifying primary bile acids synthesized in the liver into secondary bile acids through interactions with gut bacteria (138)
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