And importantly, clinicians should remain open to considering rare diagnoses like ROHHAD when the phenotype includes hypoventilation, autonomic dysregulation, or extreme hyperphagia. Perhaps one of the most exciting takeaways is that this patients hyperphagia improved markedly (and likewise quickly worsened during medication interruptions), suggesting that some of her hyperphagia was being modulated by GLP-1 RA therapy
This is the discovery of a population-wide study that looked into adults who started taking the drug in Denmark
Men on testosterone therapy who received 500 IU of HCG every other day maintained intratesticular testosterone levels 26% above baseline
Additionally, GLP-1 agonists suppress glucagon secretion from pancreatic alpha cells, slow gastric emptying, and promote satiety through central nervous system effects, contributing to weight loss in many patients
Clinical review of how glucagon-like peptide-1 agonist obesity medications decrease sexual desire, and a biopsychosocial model for why we don't 'see' it