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The effectiveness of the drug may decrease, and it may not provide the intended benefits

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As a result, patients can confidently navigate their treatment journeys with support that is faster, smarter, and more personal

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Key Takeaway: Retatrutide is moving quickly through trials, but approval timing is still uncertain until regulators review the full evidence

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This guide breaks down exactly what happens in your body after each semaglutide injection , when the most common side effects typically appear, how long they last at each dose level, and what the STEP trial data actually shows about the timeline from first injection to peak side effects

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It also matters because dehydration from vomiting or diarrhea is easier to manage when you are awake and can sip fluids consistently

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