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Originally, semaglutide was created for type 2 diabetes

Hanna, S., Sethiadi, J., Ali, Q., & Sinha, S

By simultaneously activating GIP, GLP-1, and glucagon receptors, the peptide orchestrates a comprehensive metabolic response that addresses various aspects of energy homeostasis and glucose regulation

Neither BPC-157 nor TB-500 is FDA-approved, and the FDA has specifically flagged BPC-157, so these remain research-stage compounds discussed only in a wellness-support context