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In animals, GSH synthesis is regulated by feedback inhibition based on cysteine availability and the balance between the catalytic and regulatory subunits of glutamate-cysteine ligase (GCL) (Fraser et al., 2003

Beyond Barriers is confident the results will be more robust when delivered intranasally. Using a repurposed drug lets the company pursue the 505(b)(2) FDA approval pathway, which Kole says, has a three-fold better chance of success of approval than the traditional 505(b)(1) route and is less expensive and time-intensive. Administration doses and schedules are to be determined, but early research suggests the administration window may be as long as 72 hours after injury

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Similar content being viewed by others Subjects Acknowledgements This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2020R1I1A3A04038150), Korea Basic Science Institute (National research Facilities and Equipment Center) grant funded by the Ministry of Education (2023R1A6C101A045), and the NRF grant funded by the Korea government (MSIT 2020R1A2C2103067)