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This effect is most pronounced after initial doses and diminishes with continued treatment
Losing weight can alleviate physical strain, improve mobility, and reduce the risk of conditions associated with obesity, such as heart disease and diabetes
Additive effects on weight loss were similarly demonstrated in the Efficacy and Safety of Semaglutide Once-weekly Versus Placebo as add-on to SGLT-2i in Subjects With Type 2 Diabetes Mellitus (SUSTAIN-9) and Dulaglutide as add-on therapy to SGLT2 inhibitors in patients with inadequately controlled type 2 diabetes (AWARD-10) trials [103,104]
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