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Researchers generally describe these effects as dose- and duration-dependent rather than inherent to any exposure level
Circulation: Cardiovascular Quality and Outcomes
Doseresponse relationships for both agents were nonlinear, with greater incremental effects at lower doses and attenuation at higher doses, although the shape and extent of these relationships differed between drugs
The increased risk of suicidal thoughts or behavior with AEDs was observed as early as 1 week after starting drug treatment with AEDs and persisted for the duration of treatment assessed
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