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Coupled with their high molecular weight and high polarity, it is usually difficult to penetrate the gastrointestinal epithelial cell membrane, resulting in low oral bioavailability
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To the best of our knowledge, this is the first intervention study evaluating the effects of SGLT-2Is and GLP-1RAs on DWI-MRI
It is widely available and inexpensive
however, the precise contribution of this pathway in humans is not yet fully characterised
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