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A key differentiator of Mardrigals resmetirom is that in a pivotal Phase 3 trial, it achieved both primary endpoints of NASH resolution and reduction in fibrosis (MAESTRO-NASH), the two liver histological improvement endpoints the FDA has proposed as reasonably likely to predict clinical benefit

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The time it took for the rat to retract its tail, with a cut-off time of 15 s, was closely observed and recorded as the tail withdrawal latency (Mokhemer et al

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Since then, the published literature has expanded dramatically