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Furthermore, C18:1-carnitine has been demonstrated to function as an efficacious noncompetitive inhibitor of GlyT2, which has the potential to serve as an analgesic by regulating the transport of glycine in the central nervous system (CNS) and influencing the concentration of this pivotal inhibitory neurotransmitter [112]

Systematic reviews of studies conducted in perioperative patients taking GLP-1 agonists found larger volumes of solid food in the stomach even after adequate fasting preoperatively and a higher rate of (post operative nausea and vomiting.7,8 The ASA also recommend withholding GPL-1 agonists preoperatively.9 Emergency clinicians should treat these patients as higher risk during procedural sedation or intubation and prepare accordingly

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