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Methods Ethical approval All animal experiments reported herein were performed following the guidelines and were approved by Peking University Institutional Animal Care and Use Committee (LA2021316)

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These findings affirm that SGLT-2is may be regulating energy homeostasis and cardiovascular control via the central pathway, which is an important underlying mechanism with beneficial clinical implications

Tirzepatide is not recommended for individuals with a personal or family history of medullary thyroid carcinoma or those diagnosed with multiple endocrine neoplasia syndrome type 2, due to a theoretical risk of thyroid tumors based on animal studies