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PKC activation disrupts normal metabolism, leading to ATPase phosphorylation and metabolic disorders, including changes in VEGF and vasoconstriction, which affect pain perception
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The healthy heart has metabolic flexibility, enabling mitochondria to adaptively utilize different substrates depending on oxygen levels, substrate concentrations, and enzyme activity to produce ATP that meets cardiac needs, with fatty acids being the most productive substrate (Actis Dato et al., 2024)
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North America held the largest share of the GLP-1 receptor agonist market in 2022 and is projected to grow at a robust CAGR through 2032
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