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A random-effects model with the DerSimonianLaird estimator was employed to synthesize main effects using inverse variance weighting

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However, a recent randomized, double-blind, controlled study, performed in 60 healthy postmenopausal women conclude that while there was a E2 decrease when giving anastrozole (an inhibitor of aromatase activity), but no changes in E2 levels were observed when fulvestrant (a selective estrogen receptor- antagonist) was administered

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At age 20, plasma contains approximately 200 ng/ml of GHK-Cu, dropping to just 80 ng/ml by age 60