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MUN reduced trophoblast differentiation into an endothelial-like phenotype To the extent of trophoblastic capacity to differentiate, we examined if trophoblasts isolated from MUN placentas could differentiate into an endothelial-like phenotype when cultured on Matrigel

doi:10.1056/NEJMcibr1315544

Notably, in these studies, the upregulation of GPx4 has been achieved by using exogenous agents (like NVP-AUY922, Bafilomycin A1, PD151746, GsMTx4, epigallocatechin-3-gallate, total flavonoids of Engelhardia roxburghiana leaves, Lycium barbarum polysaccharide-glycoprotein, perillaldehyde, melotonin, ferulic acid, and sphingosine-1-phosphate) which either inhibit the degradation of GPx4 or increase its transcription by activating the Nrf2 [67]