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Ames BN, Cathcart R, Schwiers E, Hochstein P
Gastrointestinal Distress: Acute systemic loads exceeding 10 mg frequently trigger nausea, severe cramping, and gastrointestinal rejection
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It acts as an amylin receptor agonist, activating AMY1, AMY2, and AMY3 receptors heterodimers of the calcitonin receptor with receptor activity-modifying proteins (RAMPs) to produce satiety signaling, gastric emptying inhibition, and glucagon suppression
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