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then a 20 mg/kg dose (the typical therapeutic dose) produces a gut concentration of 6000 M, assuming 75% bioavailability
One advantage: precision
It quiets food noise partly by dampening the brain's reward response to highly palatable food, which is why so many people describe food feeling "less loud" within the first weeks
Mass spectrometry is used to verify that the main peak from the HPLC is, in fact, the correct peptide
The 1.0 mg jump is often the most challenging, with nausea rates climbing to 30 to 35 percent and lasting up to two weeks
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