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Critically, AOD-9604 does not elevate IGF-1 levels or impair glucose metabolism, distinguishing it from full-length GH

[8] Overall, these side effects are short-lived and manageable, often improving by slowing the rate of administration or taking breaks during an intravenous infusion if needed

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Given that impaired autophagy and dysregulated mucin secretion are key contributors to barrier dysfunction, TB-500s regenerative and anti-inflammatory actions may indirectly support mucin2 production and mucus layer integrity, though direct evidence in colitis models remains limited

Healthcare providers must consider these to pick the best formulation and dosage