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This review presented fundamental information regarding two categories of GLP-1 receptor agonists (GLP-1RAs): peptide-based and small molecule compounds, and elaborated their potential neuroprotective effects by inhibiting neuroinflammation, reducing neuronal apoptosis, and ultimately improving cognitive function in various neurodegenerative diseases

This includes having the same active ingredient, similar dosage strength, and the same route of administration

Study participants started at lower doses around 1 mg weekly, with increases up to 12 mg weekly in some trials

Clinical consensus, reflected in ADA Standards of Care 2024, supports dose delay as the preferred first step