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If neurological symptoms are present, treatment is more intensive: 1 mg on alternate days until no further improvement occurs, then maintenance doses of 1 mg every 2 months

The combination has one preclinical synergy paper but no human trial data of its own

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However, in agreement with a causal role of moderately elevated circulating homocysteine levels in cardiovascular disease, some putative mechanisms have been identified that may explain the atherothrombogenicity of hyperhomo- cysteinemia

These formulas are suitable for individuals who experience fatigue, stress, or insufficient rest