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In adolescents, consider: Gastroenteritis Appendicitis DKA Increased intracranial pressure Fifth , one should determine whether the child is febrile or afebrile

The medication's effect on bowel habits appears highly individualised, influenced by factors such as baseline gut function, dietary habits, hydration status, concurrent medications, and the specific dose being administered

Individual timelines vary based on starting dose, titration speed, and baseline fitness

This was also shown for subjects with both type 2 diabetes and renal impairment based on data from clinical studies (Figure 3)

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