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[8] The predicted hairpins (named A-F) have strong evolutionary conservation and 3 of the predicted RNA structures (hairpins A, C and D) have been confirmed by in-line probing analysis
doi:10.2165/00003088-200342110-00002
The compound has been studied in trials lasting up to 68 weeks, which provides useful medium-term data but leaves questions about effects beyond 2 years of continuous use
For many patients, there may be long periods with no symptoms at all, followed by flare-ups
Generalized linear mixed effects models were used to compare the low carnitine status with the normal carnitine status on percent change from previous timepoint in seizure frequency, seizure severity, BHB level, number of side effects, fasting triglyceride, weight and BMI, where identity links were used for normally distributed outcome
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