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Vitamin B12 is water-soluble, which means your body is incredibly smart about handling it

Mg Units (40 mg vial + 2.0 mL BAC water = 20 mg/mL) Weekly dose 2.5 mg Volume 0.125 mL U-100 syringe units 12.5 units Weekly dose 5 mg Volume 0.25 mL U-100 syringe units 25 units Weekly dose 7.5 mg Volume 0.375 mL U-100 syringe units 37.5 units Weekly dose 10 mg Volume 0.50 mL U-100 syringe units 50 units Weekly dose 12.5 mg Volume 0.625 mL U-100 syringe units 62.5 units Weekly dose 15 mg Volume 0.75 mL U-100 syringe units 75 units On a 0.5 mL / 50-unit syringe, 12.5 mg and 15 mg need a larger syringe

The dosing schedule begins with a small introductory dosage of 0.25 mg and is increased slowly until a therapeutic dosage (a dose which provides good hunger suppression, minimal side effects, and consistent weight loss) is reached or the highest FDA-approved dose, 2.4 mg, is reached

Psychiatry 111, 110148

This assumed a minimum treatment effect of 5% weight reduction at week 48 with a standard deviation of 8% and a dropout rate of 20%