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[2] [3] However, when a gallstone obstructs the bile duct and causes acute cholestasis, a reflexive smooth muscle spasm often occurs, resulting in an intense cramp-like visceral pain in the right upper part of the abdomen known as a biliary colic (or "gallbladder attack")

For neuroprotection protocols, standard dosing uses 0.25 to 0.5 mg daily via subcutaneous or oral administration