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Nevertheless, poor diet, toxins, medications, stress, and illness can deplete its levels

These factors all impact your oxidative load

Using siRNAs, we specifically knocked down mRNA expression of each of these (Figure 6C)

This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH