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According to him 'this was contrary to everything that was then believed about the physiological role of glucagon in glucose homeostasis if indeed there was one.' Just a couple of years before, Yalow and Berson had detected larger than normal rises in the plasma insulin levels in insulinoma patients injected with glucagon, but concluded this was due to insulin released from the liver
This means it is considered dangerous and can be addictive and that physical and psychological addiction is possible if you take this prescription drug
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The mechanism is plausible, the animal data is consistent, and there is no reason to take the risk
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