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Based on Phase 2 trial data, the most common early side effects are nausea, vomiting, diarrhoea, constipation, and reduced appetite, consistent with the GLP-1 receptor agonist class

Study: Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial

A cool, comfortable temperature is also crucial, as the bodys core temperature naturally drops during sleep