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279 The phase 3 HELIOS-B trial (NCT04153149), a multicenter, double-blind, randomized controlled trial, recently reported that vutrisiran reduced the primary endpoint, a composite of all-cause mortality and recurrent cardiovascular events, by 28% in the overall population and by 33% in the monotherapy subgroup
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In the occipital cortexa region associated with visual processing and also implicated in emotional regulationglutathione concentrations were significantly lower in individuals with MDD compared to controls
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