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Upregulation of oxidative mitochondrial metabolism is an accepted method of resistance to other therapeutic interventions in various diseases, such as pancreatic cancer and acute myeloid leukaemia 67,68

GDF-11 neutralisation may accelerate cardiac ageing in extended exposure studies monitoring required)

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In a subset of the Phase 2 trial, Retatrutide led to the resolution of hepatic steatosis in over 85% of participants receiving the higher doses

Its ability to target both GLP-1 and GIP receptors makes it more effective than older drugs