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Originally developed to treat diabetes, GLP-1 agonist medications, such as Wegovy, Ozempic, Mounjaro, and Zepbound, have evolved into one of the fastest-growing and most disruptive drug classes in modern healthcare
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Current guidelines from the European Society of Cardiology and American Diabetes Association strongly endorse GLP-1 receptor agonists with proven cardiovascular benefit for patients with established atherosclerotic cardiovascular disease
doi: 10.1056/NEJMoa2206286 66 BhattDLSzarekMStegPGCannonCPLeiterLAMcGuireDKet al
Activation of these pathways promotes the key of pro-inflammatory cytokines (IL-1, IL-6, and TNF- ) and chemokines (CXC, CC, CX3C, and XC), exacerbating inflammations and tissue injury
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![Composite primary outcome in PIONEER 6 [25]. Cumulative incidence plots](https://www.researchgate.net/publication/343772424/figure/fig1/AS:1024481283817472@1621266780897/Composite-primary-outcome-in-PIONEER-6-25-Cumulative-incidence-plots-for-the-primary.png)
