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Compounded tirzepatide formulations containing vitamin B12 typically appear pink to light red, contrasting with FDA-approved tirzepatide (Mounjaro, Zepbound), which is clear and colorless to slightly yellow

Digestive changes may also affect appetite patterns and eating frequency during the first weeks of use

If left untreated, it can progress from a mild, non-proliferative stage to moderate and severe stages, eventually leading to PDR, in which the formation of fibrotic membranes promotes retinal detachment and vision loss [4, 5]

In addition, discontinuation was higher among those ages 65 and older