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Antiinflammatory actions of glucagon-like peptide-1based therapies beyond metabolic benefits Text PDF Abstract Therapies based on glucagon-like peptide-1 (GLP-1) reduce rates of cardiovascular and chronic kidney disease in people with type 2 diabetes and/or obesity, with ongoing clinical trials investigating their effects in people with metabolic liver disease, arthritis, and both substance use and neurodegenerative disorders
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At the same time, bile acid signaling pathways, including the farnesoid X receptor (FXR)FGF15 and TGR5glucagon-like peptide-1(GLP-1) axes, are disrupted, further promoting hepatic lipid accumulation and immune dysregulation
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