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This is primarily a fueling issue
Head-to-head comparison The SURPASS-2 trial compared tirzepatide directly against semaglutide 1.0mg (not the higher 2.4mg weight management dose)
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A head-to-head comparison worth noting: the ACT NOW trial (N=602) showed pioglitazone reduced conversion from prediabetes to type 2 diabetes by 72% over 2.4 years, outperforming metformin's 31% reduction in the DPP trial [8]
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