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Phentermine is generally a lower-cost option, while GLP-1 medications like semaglutide can be more expensive and have variable insurance coverage

While real-world data on the level of adherence to dual GLP1-RA/GIP agonists are not available to date, some considerations can be drawn from available clinical trials and experiences with other pharmacological classes

Further, at 36 months, the cumulative incidence of NAION was 8.9% (95% Confidence interval [CI], 4.5% to 13.1%) for the semaglutide cohort 1.8% (95% CI, 0% to 3.5%) for the non-semaglutide cohort Moving on to the obese and overweight group Out of the 979 participants included in this group, NAION developed in 20 and 3 patients from the semaglutide and non-semaglutide cohorts, respectively

"Novo Nordisk A/S: Wegovy pill approved in the US as first oral GLP-1 for weight management" (Press release)

Helsted MM, Schaltz NL, Gasbjerg LS, Christensen MB, Vilsboll T, Knop FK