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An overview of DNA repair in amyotrophic lateral sclerosis

Sorafenib inhibits the phosphorylation of the eukaryotic translation initiation factor 4E-binding protein 1, a key negative regulator of translation controlled by mTOR (Sauzay et al., 2018), (Rosenberg et al., 2018)

These data demonstrate that co-treatment with a moderate dose of ferrous iron and an APAP overdose again switches the mechanism of cell death from mitochondria dysfunction-centered necrosis to LPO as the dominant mechanism of cell death [81]

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Designed for use in strictly controlled in vitro and preclinical models