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The FLOW trial demonstrated that semaglutide slowed CKD progression in patients with type 2 diabetes and CKD, while SURPASS-4 showed that tirzepatide was associated with reduced albuminuria progression compared to insulin glargine in patients with type 2 diabetes
Baseline and periodic monitoring might include: Complete blood count to assess for anemia Ferritin levels (iron stores), with management of documented iron deficiency per clinical guidelines Vitamin D, B12, and folate levels Zinc levels if deficiency is suspected based on clinical presentation Thyroid function tests to exclude concurrent thyroid dysfunction A standard multivitamin may be appropriate for individuals with significantly reduced food intake, with targeted supplementation based on laboratory results
Thus, current efforts are focused on preserving basal autophagy levels in podocytes, a goal achievable through the administration of antioxidant compounds such as berberine, mangiferin, notoginsenoside R1, and geniposide (81)
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