Presented for research literature review only Famularo G et al
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Recent research into microglia and HIV-1 factors has underscored the central mechanisms involved in this process include NLRP3 inflammasome activation (e.g., GSDMD, GSDME, NEK7, ASC, caspase-1 and IL-1) and NF-B signaling pathways (e.g., NF-B, P2X7R, IKK, nuclear translocation inhibitors, DNA binding inhibitors), along with cellular processes such as autophagy (e.g., PINK1, Parkin and DNM1L), ferroptosis (e.g., FTH1, ACSL4, miR-204, and GPX4), and senescence (e.g., miR-505 and SIRT3), highlighting critical targets for further investigation and therapeutic intervention in NeuroHIV
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The peptide has demonstrated efficacy in normalizing pathological blood pressure states, reversing hypertension induced by NOS inhibitors and attenuating hypotension induced by excessive NO substrate administration, indicating adaptive vascular regulation
