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Key red flags include pregnancy (no safety data, so contraindicated), active cancer (caution due to growth effects), autoimmune disorders, or organ failure
ESC Heart Fail 5(6):10351043 Lepore JJ, Olson E, Demopoulos L, Haws T, Fang Z, Barbour AM, Fossler M, Davila-Roman VG, Russell SD, Gropler RJ (2016) Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction
In addition, both public and private insurance providers use various cost-containment measuressuch as requiring prior authorizationthat can be adjusted over time
ACE Inhibitors (Angiotensin-Converting Enzyme Inhibitors) Mechanism: Block conversion of Angiotensin I II vasoconstriction & aldosterone Examples: Enalapril, Lisinopril, Captopril Key Points: Protective in diabetic nephropathy, heart failure Caution: Avoid in pregnancy
These medications work by either stimulating the body to produce more platelets or by reducing the destruction of platelets
