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One small RCT in patients with cirrhosis showed significant reduction in cramp severity with no sodium-related complications, even among those with ascites [98]
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They include non-hormonal therapies like lubricants and vaginally applied nutrient therapies, as well as low- and ultra-low-dose vaginal preparations that supply estrogen directly to the vaginal tissue
Liver scarring is very serious, with the potential to disrupt the organs functionality and potentially lead to liver failure
Useful measures include longitudinal lactate/pyruvate ratios, pH-sensitive imaging, MCT1/2/4 expression, and magnetic resonance spectroscopy
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