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34 The findings on gut microbiota and TS are largely consistent in highlighting the role of dysbiosis, gut-brain axis dysfunction, and neuroinflammation in the pathophysiology of TS
Databases searched (and their content coverage dates) were Ovid MEDLINE(R) (1946+ including epub ahead of print, in-process, and other nonindexed citations), Ovid Embase (1974+), Ovid APA PsycInfo (1967+), Ovid Cochrane Central Register of Controlled Trials (1991+), Ovid Cochrane Database of Systematic Reviews (2005+), Web of Science Core Collection via Clarivate Analytics (1975+), and Scopus via Elsevier (1974+)
So a 12.5% deficit at your starting weight becomes a smaller deficit at a lower weight, even if your eating stays exactly the same
Balancing the risks of using these agents with any potential benefits on muscle function is therefore essential in selecting agents both for future study and for the design of trials examining their effects on skeletal muscle function in older people
No, Im not afraid of needles
