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3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)

While B12 is crucial for the optimal functioning of the intestines, damaged or diseased intestines face difficulty absorbing B12 from food sources

Lugano R, Ramachandran M, Dimberg A

This allows the intact tripeptide to safely reach the lower intestinal tract, where it is gradually released and absorbed over an extended period