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In type 1 diabetes, studies of GLP1-RAs as an adjunctive therapy to insulin have focused on glycaemic control and body weight reduction (Table 1)
People using oral contraceptives Slowed gastric emptying can reduce oral contraceptive absorption when starting tirzepatide
Furthermore, post hoc subgroup analyses of cardiovascular outcome trials have suggested a greater cardiorenal protection in patients treated with a combination versus either monotherapy
The fixed-ratio nature of the blend also means components cannot be titrated independently: any adjustment scales all four peptides together
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