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(D) Schematic of glutathione metabolism, along with a dot plot visualizing genes involved in glutathione metabolism, displaying average expression and percentage expressed in PEC and IC-B cells from ABMR (red) and healthy kidney samples (black)
Mitochondria-targeted ATs (e.g., mitoquinol) have also shown potential
Popular items include alpha-lipoic acid, methyl-sulfonyl-methane (MSM), allicin (the main active ingredient in garlic), glucosamine sulfate (and its natural polymer, chondroitin), SAMe (S-adenosylmethionine), and several important antioxidants, such as glutathione, N-acetylcysteine (NAC) and dimethyl-sulfoxide (DMSO)
Thioredoxins reduce disulfide bonds in oxidized proteins, converting them back to their functional thiol form (Silva-Adaya et al., 2014)
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