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The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins
One theoretical concern is that the same angiogenesis-promoting properties that aid healing could potentially have unintended effects
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The most accurate Reddit observations align with clinical data: retatrutides triple mechanism produces superior weight loss, the glucagon component increases energy expenditure noticeably, and GIP activation may reduce GI side effects compared to pure GLP-1 agonists
In the pig data, plasma IGF-1, IGFBP-3, and growth hormone were all reduced by LR3 infusion (Tomas et al., 1997)
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