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Senna contains compounds called sennosides, which promote the movement of matter through your digestive tract, as well as intestinal fluid accumulation, to relieve constipation ( In a high quality 28-day study, researchers gave 1 g of senna daily to people with constipation
However, some patients may stop because of side effects, cost, and accessibility
Dose adjustments of these medications may be required when starting GLP-1 therapy, regardless of timing
However, a recent survey of data from Medicare beneficiaries, older than 65 years of which 55% had baseline CVD, did not demonstrate increased risk of stroke, myocardial infarction or heart failure when comparing DPP-4 inhibitors with sulfonylureas (SU) or thiazolidinediones (TZDs) [26]
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