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Considerable interest exists in identifying effects of these drugs beyond glucose-lowering, possibly resulting in improved macrovascular and microvascular outcomes, including in diabetic kidney disease

The drug is available in branded forms such as Ozempic and Wegovy, which have undergone rigorous testing and regulatory approval

State regulations vary, and professional boards may interpret the issue differently

There is enormous exuberance about starting GLP-1 drugs, but not nearly enough attention to what happens when people stop, said senior author Ziyad Al-Aly, MD, a WashU Medicine clinical epidemiologist and chief of the Research and Development Service at the VA Saint Louis Health Care System

Research method and findings To study how GLP-1 receptor agonists affect muscle and fat, the HKUMed research team used genetic data of over 800,000 European participants from different genome wide association studies (GWAS)