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Some people who experience mild nausea find that evening dosing lets them sleep through the brief nausea window that occurs 1 to 2 hours after absorption

This is why a primary concern with microdosing is that people may not obtain the necessary amount of the GLP-1 drug to have the desired therapeutic outcome, such as weight loss

2011 Dec 1;9(1):216

Preliminary research suggests that GLP-1s may improve menstrual regularity and increase fertility rates among people with obesity with hormonal disorders like polycystic ovarian syndrome (PCOS)